THIS SITE IS INTENDED FOR HEALTHCARE PROFESSIONALS ONLY.

Speak with a representative
Speak with a
representative
to learn more
To request a discussion about Nalmefene with a representative, please provide the following information.
*Indicates required field.
There was an error in one of the required fields. Please review the form and submit again.
First name is a required field
First name*

Last name*
Last name is a required field

Use this link https://npiregistry.cms.hhs.gov/ to look up your NPI number.
NPI number
Institution*
Institution is a required field

Zip Code*
ZIP Code is a required field

Phone number

Email address*
Email address should be in format name@domain.com

Confirm email address*
Please confirm email address

You must agree to terms below:

Submit
 
Thank you. We have recieved your information and a representative will be in touch with you soon.
Continue
You are now leaving nalmefenehcl.com
Purdue Pharma L.P. accepts no responsibility for any of the content on the linked site.
Do you wish to leave nalmefenehcl.com?
No
Yes
 

Nalmefene HCl offers an additional overdose reversal option1

High binding affinity to opioid receptors2,3
Reverses opioid effects, including respiratory depression, sedation, and hypotension1
Duration of action as long as most opioid analgesics1
10.8-hour mean terminal elimination half-life1,*
Safety and tolerability similar to naloxone1
 
In 1995, Nalmefene HCl Injection was approved by the FDA for use as an opioid overdose reversal medication under the brand name Revex®. It was withdrawn from the US market in 2008 by its manufacturer for reasons other than safety or effectiveness. The trials are based on studies conducted with Revex.4
Nalmefene was studied in 284 patients presumed to have taken an opioid overdose1
  • One of the 4 trials was a randomized, double-blind, phase 3 trial (N=176)5
Nalmefene injection doses of 0.5 mg to 1 mg effectively reversed respiratory depression within 2 to 5 minutes in most patients1
  • Dose range in clinical trials: 0.5 mg to 2 mg5
 
*Nalmefene elimination half-life is based on pharmacokinetic data. The mean terminal elimination half-life is 10.8 hours and 9.4 hours in younger (19 to 32 years) and elderly (62 to 80 years) healthy male subjects, respectively, following a Nalmefene 1 mg IV dose.1

Nalmefene HCl safety and tolerability

RELATIVE FREQUENCIES OF COMMON ADVERSE REACTIONS (INCIDENCE >1%, ALL CLINICAL SETTINGS)1

ADVERSE EVENT NALMEFENE (n=1127) NALOXONE (n=369) PLACEBO (n=77)
Nausea 18% 18% 6%
Vomiting 9% 7% 4%
Tachycardia 5% 8%
Hypertension 5% 7%
Postoperative pain 4% 4% N/A
Fever 3% 4%
Dizziness 3% 4% 1%
Headache 1% 1% 4%
Chills 1% 1%
Hypotension 1% 1%
Vasodilation 1% 1%
Nalmefene safety and tolerability profile in adult patients:
  • Adverse events were evaluated in both 152 healthy volunteers and 1127 patients who were treated for opioid overdose or for postoperative opioid reversal1
  • Nalmefene was well tolerated and no serious toxicity was observed during administration in healthy individuals when given at high doses (15x the highest recommended dose)1
  • At doses exceeding the recommended dose, Nalmefene produced symptoms suggestive of reversal of endogenous opioids, such as have been reported for other narcotic antagonist drugs. These symptoms (nausea, chills, myalgia, dysphoria, abdominal cramps, and joint pain) were usually transient and occurred at very low frequency1
Speak with a representative to learn more about Nalmefene
Request a conversation
To get ordering information and resources for Nalmefene
IMPORTANT SAFETY INFORMATION AND INDICATION

CONTRAINDICATION
Nalmefene Hydrochloride injection is contraindicated in patients with a known hypersensitivity to the product.