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IM=intramuscular; IV=intravenous; SC=subcutaneous.
Studied in 284 patients presumed to have taken an opioid overdose. Effectively reversed respiratory depression at doses of 0.5 mg to 1 mg. Dose range in clinical trials was 0.5 mg to 2 mg.1,4
Nalmefene elimination half-life is based on pharmacokinetic data. The mean terminal elimination half-life is 10.8 hours and 9.4 hours in younger (19 to 32 years) and elderly (62 to 80 years) healthy male subjects, respectively, following a Nalmefene HCl 1 mg IV dose.1
88% of all opioid overdose deaths in 2021 involved synthetic opioids.5
Nalmefene HCl doses are designed to achieve prompt opioid overdose reversal in a controlled manner.1
Nalmefene HCl is available wholesale through Purdue Authorized Distributors.
